Issue:
When using the Save & Send option from word, excel or PDF-XChange, receives the error: "Couldn't send mail because of MAPI failure: "Operation not supported".
Solution:
1. Rename Msmapi32.dll located in C:\Program Files (x86)\Common Files\System\MSMAPI\1033 or C:\Program Files\Common Files\System\MSMAPI\1033
2. Right-click the MSMapi32.dll file, and then click Rename.
3. Type Msmapi32.old, and then press ENTER to rename the file.
4. Restart the application that was displaying the error.